Skip to main content

Table 1 Baseline characteristics of the original cohort

From: Early acetaminophen administration is associated with lower mortality among ARDS patients after coronary artery bypass grafting: a retrospective study

Variables

Total (n = 5459)

Non-APAP group (n = 1532)

APAP group (n = 3927)

P value

Demographic characteristics

    

Age, years

69 [62, 76]

70 [63, 77]

69 [62, 76]

< 0.001

Sex, male, n(%)

4272 (78.3)

1177 (76.8)

3095 (78.8)

0.110

Race (%)

   

0.104

 White

3882 (71.1)

1065 (69.5)

2817 (71.7)

 

 Others

1577 (28.9)

467 (30.5)

1110 (28.3)

 

BMI, kg/m2

28.9 [25.7, 32.7]

29.0 [25.7, 33.0]

28.9 [25.8, 32.5]

0.355

Admission type (%)

   

0.023

 Elective

472 (8.7)

111 (7.3)

361 (9.2)

 

 Urgent

1749 (32.0)

521 (34.0)

1228 (31.3)

 

 Others

3238 (59.3)

900 (58.8)

2338 (59.5)

 

Surgery type (%)

   

< 0.001

 CABG

4173 (76.4)

1108 (72.3)

3065 (78.1)

 

 CABG + Valve

1286 (23.6)

424 (27.7)

862 (22.0)

 

ARDS (%)

   

< 0.001

 Mild

1664 (30.5)

371 (24.2)

1293 (32.9)

 

 Moderate

2378 (43.6)

622 (40.6)

1756 (44.7)

 

 Severe

1417 (26.0)

539 (35.2)

878 (22.4)

 

Vital signs

    

 Heart rate, bpm

81 [76, 87]

81 [77, 87]

81 [76, 87]

0.543

 MAP, mmHg

75 [71, 79]

74 [70, 78]

75 [71, 79]

< 0.001

 Respiratory rate, bpm

17 [16, 19]

17 [16, 19]

17 [16, 18]

0.002

 Temperature, ℃

36.6 [36.3, 36.8]

36.5 [36.3, 36.8]

36.6 [36.4, 36.8]

0.006

Laboratory tests

    

 WBC, 109/L

13.2 [10.4, 16.9]

13.3 [10.4, 17.0]

13.2 [10.4, 16.8]

0.486

 PLT, 109/L

156 [128, 190]

154 [126, 190]

157 [130, 190]

0.091

 Hb, g/dL

10.3 [9.3, 11.4]

10.1 [9.1, 11.2]

10.4 [9.4, 11.5]

< 0.001

 pH

7.37 [7.35, 7.40]

7.37 [7.34, 7.39]

7.37 [7.35, 7.40]

< 0.001

 PaO2, mmHg

240.3 ± 50.6

236.9 ± 50.1

241.6 ± 50.8

0.002

 PaCO2, mmHg

41 [39, 44]

41 [39, 44]

41 [39, 44]

0.141

Comorbidities

    

 Congestive heart failure, n (%)

1477 (27.1)

512 (33.4)

965 (24.6)

< 0.001

 Chronic pulmonary disease, n (%)

580 (10.6)

184 (12.0)

396 (10.1)

0.038

 Diabetes, n (%)

2399 (44.0)

737 (48.1)

1662 (42.3)

< 0.001

 Cerebrovascular disease, n (%)

584 (10.7)

191 (12.5)

393 (10.0)

0.008

 Peripheral vascular disease, n (%)

740 (13.6)

256 (16.7)

484 (12.3)

< 0.001

 Chronic renal disease, n (%)

1082 (19.8)

363 (23.7)

719 (18.3)

< 0.001

Clinical scoring systems

    

 OASIS

33 [29, 38]

33 [29, 38]

33 [28, 37]

< 0.001

 SIRS

3 [2, 3]

3 [2, 3]

3 [2, 3]

0.214

 SOFA

5 [4, 7]

6 [4, 7]

5 [4, 7]

< 0.001

Clinical outcomes

    

 14-day mortality (%)

62 (1.1)

42 (2.7)

20 (0.5)

< 0.001

 30-day mortality (%)

87 (1.6)

56 (3.7)

31 (0.8)

< 0.001

 60-day mortality (%)

125 (2.3)

71 (4.6)

54 (1.4)

< 0.001

 90-day mortality (%)

150 (2.8)

81 (5.3)

69 (1.8)

< 0.001

 Hospital stay, days

5.0 [4.1, 6.9]

5.5 [4.3, 8.0]

4.9 [4.0, 6.2]

< 0.001

 Duration of MV, daysa

0.4 [0.2, 0.8]

0.6 [0.3, 1.0]

0.3 [0.2, 0.7]

< 0.001

  1. APAP, acetaminophen; BMI, body mass index; CABG, coronary artery bypass grafting; ARDS, acute respiratory distress syndrome; MAP, mean arterial pressure; WBC, white blood cell; PLT, platelet; Hb, hemoglobin; PaO2, arterial oxygen pressure; PaCO2, carbon dioxide pressure; OASIS, Oxford acute severity of illness score; SIRS, systemic inflammatory response syndrome; SOFA, sequential organ failure assessment; MV, mechanical ventilation
  2. a Among the 5459 patients, MV records were available for 4481 patients, with 3233 in the APAP group and 1248 in the Non-APAP group
Back to article page

Journal of Cardiothoracic Surgery

ISSN: 1749-8090

Contact us