Fig. 2

Multivariable cox regression model for mortality

Association between NTproBNP and mortality analyzed using multi-variable Cox regression model. NTproBNP was entered as a time-dependent covariate modeling multiple measures per patient and using cubic spline, with heart transplantation as the competing event. The reference for the cubic spline analysis was set to median measurement of NTproBNP for the cohort, 244 pmol/L. The multivariable analysis was adjusted for age, gender, diabetes, and ischemic cardiomyopathy as the etiology of heart failure.