Fig. 3

Porcine Heart Following Myocardial Infarction Modeling and Heart Patch Treatment. a Representative image of the porcine myocardial infarction model following heart patch application. b Quantification of the infarct area after eight weeks of intervention, assessed using MRI measurements. Data were analyzed using one-way ANOVA for non-parametric comparisons, with p > 0.05 considered not significant. The figure presents MRI images of infarcted hearts (top left column), corresponding MRI interpretations (second column), and transverse sections of the heart at the infarct site, marked by a black circle (e, i, m) (transverse section at point three from Fig. 3a). The rightmost column (f, j, n) shows sections of the infarct center, indicated by red arrows. The top row represents the control group (c–f), the middle row corresponds to the pASC group (g–j), and the bottom row depicts the coculture group (k–n). The infarct area was visualized using late gadolinium enhancement (LGE) MRI contrast. Scar thickness and severity were mapped, converted into densitometry graphs, and analyzed using IntelliSpace Portal 9.0 (d, h, l)