Fig. 4

Downregulation of miR-624-3p neutralized the effects of si-circ-PSMB1 in ox-LDL-treated HAECs. (A) The miR-624-3p levels were measured by qRT‒PCR after miR-624-3p mimic and inhibitor treatment. After si-circ-PSMB1 and miR-624-3p inhibitor transfection, (B) cell viability was measured by MTT assay, (C) the pyroptosis rate was analysed by flow cytometry, (D) LDH levels were measured with the corresponding kit, (E-F) IL-1β and IL-18 levels were determined by qRT‒PCR, and (G) the protein expression levels of NLRP3 and GSDMD-N were analysed by western blotting